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KMID : 0604520210470010049
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Journal of the Society of Cosmetic Scientists of Korea
2021 Volume.47 No. 1 p.49 ~ p.56
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Skin Barrier Function Enhancement Effect about Ceramide Liquid Crystal Emulsion: Similar Ratio of Skin Lipid Composition
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Han Ji-Hye
Lee Ju-Yeon
Lee Kwan-Hyoung
Kim Hee-Sun
Park Chang-Yeol
Maeng Ji-Hye
So Ji-Min
Nam Gae-Won
Kim Sang-Chul
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Abstract
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In this study, a liquid crystal emulsion with a composition ratio similar to the skin lipid composition was manufactured using ceramide, glycolipids, cholesterol, and fatty acids, and a polarized microscope was used to identify liquid crystal particles in the formulation, and a cryso-SEM was used to confirm the formation of a multilayer structure.
The above samples were stored at room temperature for one month and the liquid crystal structure was continuously maintained through microscopic observation. In addition, a cream composition containing liquid crystal emulsion was manufactured, and the efficiency of ceramide skin penetration was confirmed using three-dimensional artificial skin. Clinical trials were conducted using the cream composition and the results of clinical trials on skin barrier improvement were confirmed by measuring skin moisture retention ( skin hydration) and transepidermal water loss (TEWL) o f subjects compared to general emulsion.
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KEYWORD
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ceramide, gucosyl ceramide, liquid crystal emulsion, skin barrier function, skin permeation
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